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Emisphere Technologies, Inc.

Drug Names(s): oral heparin

Description: Oral heparin is a formulation of the anticoagulant heparin, which currently must be injected, using Emisphere'sproprietary compound Sodium N-[8(-2-hydroxybenzoy l) amino] caprylate (SNAC), a delivery agent that can be combined with heparin to mediate itsgastrointestinal absorption by a passive transcellular process, withoutapparent damage to intestinal epithelium. The formulation under development is a solid form of oral heparin.

Deal Structure: In 1996, the Emisphere formed a joint venture with Elan Pharmaceuticalsfor the development of an oral heparin. In July 1999, however, they reacquired allproduct, marketing and technology rights for these heparin product candidatesfrom Elan.

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