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Oral Salmon Calcitonin

Emisphere Technologies, Inc.

Drug Names(s): SMC021

Description: Calcitonin is a polypeptide hormone secreted by the parafollicular cells of the thyroid gland. Calcitonin enables the bone to retain more of its mass and functionality by inhibiting the bone-tissue resorbing activity of specialized bone cells called osteoclasts. Calcitonin is involved in the regulation of calcium and the decrease of bone loss and fractures. Calcitonin derived from salmon is estimated to be about 30 times more potent than the human version. Synthetic salmon calcitonin, which is identical to the natural salmon calcitonin, is currently available only as nasal spray or as an injectable therapy.

Deal Structure: In December 1997, Emisphere entered into a collaboration agreement with Novartis Pharma AG (Novartis) to develop an oral salmon calcitonin (used in the treatment of osteoporosis). In February 2000, Novartis executed a license agreement for the development of an oral form of salmon calcitonin. In March 2000, Novartis paid Emisphere $2.5 million to obtain the license to its technology for calcitonin and to obtain an option to use the eligen technology for a second compound. Although Novartis' rights to certain financial terms concerning a second compound have expired, Emisphere and Novartis remain in discussion to develop additional compounds using Emisphere's technology, and a number of viable second compound candidates are under consideration.

In April 2004, Unigene signed licensing and clinical supply agreements with Novartis Pharma AG to provide for the recombinant production of salmon calcitonin. Under the terms of this license, Unigene is eligible to receive a total of $18.7...See full deal structure in Biomedtracker

Partners: Nordic Bioscience Unigene Laboratories, Inc.

Oral Salmon Calcitonin News

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