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Drug Names(s): Tezacitabine
Description: Tezacitabine is a novel nucleoside analog with a dual mechanism of action. It is both a potent inhibitor of ribonucleotide reductase and a DNA chain terminator. In pre-clinical studies, tezacitabine induces apoptosis and inhibits Vascular Endothelial Growth Factor (VEGF), which appears to be required for angiogenesis in many types of tumors. Tezacitabine has demonstrated synergism with radiation and with other marketed cytotoxic agents such as Ara-C and cisplatin.
Pink Sheet Chiron Ends Tezacitabine Development
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