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GlaxoSmithKline plc

Drug Names(s): HGS-ETR1, HGS1012, TRAIL-R1 mAB, TRM-1

Description: HGS-ETR1 is an agonistic human monoclonal antibody that specifically binds to the TRAIL receptor-1 protein, induces apoptosis in human cancer cell lines expressing the TRAIL receptor-1 protein, and has anti-tumor activity in a broad range of tumor types, both as a single agent and in combination with chemotherapy. TRAIL receptor 1 often is referred to as a “death receptor” because of its ability to cause apoptosis in tumor cells when it is triggered by the natural ligand TRAIL (tumor necrosis factor apoptosis-inducing ligand). Because HGS-ETR1 mimics the activity of native TRAIL, it is considered an agonistic antibody.

Deal Structure: GlaxoSmithKline exercised its option in August 2005 to develop and commercialize HGS-ETR1 jointly with Human Genome Sciences.

As part of its June 1996 agreement with GSK, Human Genome Sciences granted a 50/50 co-development and co-promotion option to GSK for certain Human Genome Sciences human therapeutic products. Under the terms of the agreement, GSK and Human Genome Sciences will share equally development costs and sales and marketing expenses and profits of any product that is commercialized, under a co-development and co-promotion agreement, the remaining terms of which are being negotiated by the parties.

In August 1999, Humane Genome Sciences entered into an antibody license agreement with Cambridge Antibody Technology (CAT) for the development of fully human antibody therapeutics for up to three of Humane Genome Science's target human proteins. Under this 1999 agreement, Humane Genome Sciences has paid CAT $2.3 million for one milestone and fees through the end of...See full deal structure in Biomedtracker

Partners: AstraZeneca PLC Takeda Pharmaceutical Company Ltd

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