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Drug Names(s): Revimid, Revlemid, lenalidomide, CC-5013, CDC-501
IMiDs such as Revimid are novel, small-molecule, orally available analogs of thalidomide that are designed to be more potent and potentially have a better safety profile than the parent compound. Celgene's IMiDs have significantly greater immunological activity in in vitro studies. IMiDs were reported in the November 1, 2000 issue of BLOOD to enhance T-cell proliferation and interleukin (IL)-2 production. In the same report, IMiDs were also shown to be potent inhibitors of inflammatory cytokines that include TNF-alpha and IL-1beta while stimulating the anti-inflammatory cytokine IL-10.
Another major target may be the ligase protein, cereblon (CRBN; http://www.nature.com/leu/journal/v26/n11/full/leu2012119a.html).
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