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Aranesp

Amgen, Inc.

Drug Names(s): darbepoetin alfa, Nespo, NESP, KRN321

Description: Aranesp is a hyperglycosylated form of erythropoetin (epo) with a longer half-life than standard epo.

Aranesp can be administered less frequently than Epogen or Procrit.

Deal Structure: Amgen has had to share rights to its first-generation recombinant epo product with Johnson & Johnson. Epogen is marketed by Amgen in the United States for chronic renal failure. Johnson & Johnson sells epo as Procrit in the U.S. for all non-renal indications and in Europe as Eprex for all indications. By contrast Amgen has retained all U.S. and European rights to Aranesp.

Amgen has an agreement with Kirin to jointly develop Aranesp through its joint venture, Kirin-Amgen. Amgen manufactures and market darbepoetin alfa in the United States, all European countries, Canada, Australia, New Zealand, Mexico, and all Central and South American countries. Kirin has similar rights for Japan, China, Taiwan, Korea, and certain other countries in Southeast Asia.

Partners: Kyowa Hakko Kirin Co., Ltd.


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