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ABT-874

AbbVie Inc.

Drug Names(s): J695, anti–Interleukin-12, briakinumab, Ozespa (EU)

Description: ABT-874 is a fully human anti-IL-12/23 monoclonal antibody designed to target and neutralize IL-12, a protein that regulates inflammatory response and is expressed in MS lesions.

Deal Structure: CAT, in conjunction with Abbott, has isolated and optimised human monoclonal antibodies against the first two nominated targets, TNF alpha and Interleukin-12, and these antibodies are now in clinical trials (HUMIRA and ABT-874 respectively). The development of ABT-874 involved the partnership of Abbott and the Genetics Institute (a research unit of Wyeth-Ayerst Laboratories, the pharmaceutical division of American Home Products) together with CAT.

In June 2006, CAT became a subsidiary of AstraZeneca.

Partners: AstraZeneca PLC


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