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Drug Names(s): XL228
Description: XL228 is an inhibitor of several tyrosine kinases implicated in the growth, proliferation and metastasis of cancer cells. The compound inhibits the activity of the insulin-like growth factor type-1 receptor (IGF1R), SRC and BCR-ABL.
Deal Structure: GlaxoSmithKline and Exelixis have a partnership focused on the collaboration in 12 programs (XL784, XL647, XL999, XL880, XL184, XL820, XL844, XL281, XL418, XL228 and two earlier stage oncology programs). GlaxoSmithKline has the right to select from these programs up to two compounds at proof-of-concept (completion of Phase IIa clinical trial) or three compounds if GlaxoSmithKline extends the collaboration.
In June 2008, Exelixis announced that the company and GlaxoSmithKline will bring their collaboration to a conclusion on October 27, 2008.
In October 2008, Exelixis announced that GlaxoSmithKline decided not to exercise its option to license XL184, XL281, XL228, XL820, and XL844.
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