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Oral Copaxone

Teva Pharmaceutical Industries Ltd.

Drug Names(s): copolymer-1, glatiramer acetate

Description: Copaxone (Glatiramer acetate) is an approved drug for the treatment of multiple sclerosis. It is a synthetic analog of myelin basic protein, a component of the myelin that insulates nerve fibers in the brain and spinal cord. It binds to MHC molecules on T cells, preventing native myelin antigens from binding to these T cells and consequent attacks on myelin-covered nerve fibers.

Deal Structure: In February 1999, AutoImmune announced the signing of an exclusive agreement with Teva Pharmaceuticals for two applications of its proprietary technology for oral immune modulation. The agreement covers the development by Teva of an oral formulation of Copaxone.

In February 2001, Teva Pharmaceutical Industries announced the conclusion of an agreement with H. Lundbeck A/S to extend their existing strategic cooperation to include the oral formulation of Copaxone.

Partners: Sanofi AutoImmune Inc. H. Lundbeck A/S

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