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Yttrium-90 Clivatuzumab Tetraxetan

Immunomedics, Inc.

Drug Names(s): 90Y-Clivatuzumab Tetraxetan, humanized anti-MUC1 monoclonal antibody with Yttrium-90, Y-90 hPAM4

Description: hPAM4 is a humanized monoclonal antibody targeting an epitope in the MUC1 antigen expressed in most pancreatic cancer, but not pancreatitis, normal pancreas, or most other normal tissues. Preclinical studies with PAM4 labeled with the radioisotope Yttrium-90 demonstrated faborable tumor responses, which could be further improved when given in combination with gemcitabine.

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