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Alicaforsen

Atlantic Healthcare

Drug Names(s): ISIS 2302; AP 1007

Description: Alicaforsen is an antisense inhibitor of intercellular adhesion molecule-1 (ICAM-1), an important mediator of inflammation.

Deal Structure: In March 2007, Isis licensed alicaforsen to Atlantic Healthcare (UK) Limited. Atlantic Healthcare plans to initially develop alicaforsen for pouchitis, an ulcerative colitis indication, followed by ulcerative colitis and other inflammatory diseases. In exchange for the exclusive, worldwide license to alicaforsen, Isis will receive an upfront payment from Atlantic Healthcare in the form of equity valued at $2 million. In addition, assuming Atlantic Healthcare successfully develops and commercializes alicaforsen, Isis will receive milestone payments and royalties on future product sales of alicaforsen. If Atlantic Healthcare meets certain of these milestones, at Atlantic Healthcares request, Isis will attempt to identify a second generation lead drug candidate for Atlantic Healthcare. Atlantic Healthcare may take an exclusive worldwide license to the lead candidate under the terms and conditions of the agreement. Atlantic Healthcare is solely responsible for the continued development...See full deal structure in Biomedtracker

Partners: Ionis Pharmaceuticals, Inc.


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