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Ocera Therapeutics Inc.

Drug Names(s): TZP-101

Description: TZP-101 is a small molecule ghrelin receptor agonist, given intravenously. Ghrelin is a peptide hormone known to stimulate both gastrointestinal motility and growth hormone release.

Deal Structure: Ulimorelin was originally developed by Tranzyme.

In June 2010, Tranzyme Pharma and Norgine entered into a licensing agreement that provides Norgine with the exclusive rights to develop and commercialize ulimorelin (TZP-101) in Europe, Australia, New Zealand, the Middle East, South Africa and North Africa. Under the agreement, Norgine will make an upfront payment of $8 million and will also make an equity investment in Tranzyme. Further, Tranzyme is eligible to receive up to approximately $150 million if certain development, regulatory and commercial milestones are achieved. Tranzyme will also receive escalating double-digit royalties on net sales in the licensed territories. The companies will jointly fund further development of ulimorelin.

Partners: Norgine B.V.

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