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Panretin gel

Eisai Co., Ltd.

Drug Names(s): alitretinoin, Topical ALRT1057, Topical LGD1057

Description: Panretin gel 0.1% contains alitretinoin, which is a naturally-occurring endogenous retinoid that binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg,RXRa, RXRb and RXRg). Once activated, these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells. Alitretinoin inhibits the growth of Kaposi’s sarcoma (KS) cells in vitro.

Deal Structure: Ferrer and Ligand
In March 1999, Ligand signed marketing and distribution agreements with Ferrer Internacional, S.A. to exclusively market and distribute ONTAK, Panretin gel, Panretin capsules, Targretin gel and Targretin capsules, in Spain, Portugal, Greece, and Central and South America.

Alfa Wassermann and Ligand
In January 2000, Ligand signed amarketing and distribution agreement with Alfa Wassermann S.p.A. to exclusively market and distribute in Italy ONTAK, Panretin gel, Panretin capsules, Targretin gel and Targretin capsules. Ligand received from Alfa Wassermann, as reimbursement for certain registration services previously incurred by Ligand for the products, $0.75 million upon signing and will receive additional amounts aggregating up to $1.0 million upon achievement of certain milestones. Under the terms of the agreement, Alfa Wassermann will haveexclusive long-term marketing and distribution rights and responsibilities in Italy for ONTAK, Panretin...See full deal structure in Biomedtracker

Partners: Grupo Ferrer Internacional, S.A. Perrigo Company PLC Alfa Wassermann SpA Teva Pharmaceutical Industries Ltd.

Panretin gel News

Pink Sheet Ligand Panretin gel

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