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Xolair

Roche Holding AG

Drug Names(s): rhuMAb-E25, IGE025, RG3648

Description: Xolair is an anti-immunoglobulin E antibody whose therapeutic effect has been validated through clinical trials in patients suffering from allergic asthma. In June 2002, Xolair received marketing approval in Australia for treating adults and adolescents with moderate allergic asthma. It was approved in the U.S. on June 20, 2003.

Deal Structure: Revenue splits for this drug are BioMedTracker estimates.

Xolair was developed by Genentech, allegedly after Tanox attempted to partner with Genentech to develop anti-IgE monoclonal antibodies. Tanox then partnered with Ciba-Geigy, now Novartis, to developed anti-IgE monoclonal antibodies. Novartis and Genentech agreed to develop Xolair over Tanoxs TNX-901 antibody, paying a royalty to Tanox.

In February 2004, Genentech, Inc., Novartis Pharma AG and Tanox, Inc. settled all litigation pending among them, and finalized the detailed terms of their three-party collaboration, begun in 1996, to govern the development andcommercialization of certain anti-IgE antibodies including Xolair and TNX-901. This arrangementmodifies the arrangement related to Xolair that Genentech entered into with Novartis in 2000. All three parties are co-developing Xolair in the U.S., and Genentech and Novartis are co-promoting Xolair in the U.S. and both will make certain joint and individual payments to...See full deal structure in Biomedtracker

Partners: Novartis AG PDL BioPharma, Inc. DRI Capital Inc.


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