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Denenicokin

Bristol-Myers Squibb Company

Drug Names(s): BMS-982470, recombinant interleukin 21 (rIL-21), NN028

Description: IL-21 is a novel member of the 4 helical bundle cytokine family, a protein family well-validated as having therapeutic potential. IL-21 has potent biological activity in regulating key classes of immune cells, including cytotoxic T cells and natural killer cells.

Deal Structure: IL-21 was originally developed by ZymoGenetics.

Novo Nordisk and ZymoGenetics
In June 2001, Novo Nordisk gave notice of its intent to exercise an option to license rights to IL-21 outside of North America pursuantto ZymoGenetics' option agreement with Novo Nordisk.

In January 2009, ZymoGenetics announced the acquisition of ex-North American rights to Interleukin 21 (IL-21) from Novo Nordisk, resulting in ZymoGenetics owning worldwide rights to IL-21. Under the terms of the arrangement, Novo Nordisk agreed to license rest of world (ex-North American) development and commercialization rights for IL-21 to ZymoGenetics in exchange for potential regulatory approval milestones and royalties related to the ex-North American territory. In addition, upon licensing worldwide rights for IL-21 to a third party, Novo Nordisk would receive a portion of related licensing fees if a certain threshold level were exceeded.

Bristol-Myers Squibb and ZymoGenetics
In September...See full deal structure in Biomedtracker

Partners: Novo Nordisk A/S


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