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Pfizer Inc.

Drug Names(s): Sitaxentan, Sitaxsentan, PF-1228305

Description: Sitaxsentan is a small molecule selective inhibitor of the endothelin A receptor. Endothelin is a small peptide hormone that is believed to play a critical role in the control of blood flow and cell growth.

Deal Structure: In June 2000, ICOS and Encysive formed a joint venture to develop Sitaxsentan. On January 30, 2003, ICOS elected to terminate the joint venture. Encysive reacquired all rightsto the program for a closing payment of $4M with additional payments of $4M and $2M due in2004.

On June 16, 2005, Encysive Pharmaceuticals announced plans to market Thelin directly in Europe.

In April 2008, Encysive became a wholly-owned subsidiary of Pfizer.

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