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ChimeriVax-West Nile


Drug Names(s): ChimeriVax-West Nile

Description: The ChimeriVax technology utilizes yellow fever virus (YF) 17D vaccine strain capsid and nonstructural genes to deliver the envelope gene of other flaviviruses as live-attenuated chimeric viruses.

Deal Structure: Acambis is developing the ChimeriVax-West Nile vaccine using its proprietary ChimeriVax technology, which was originally developed in collaboration with St. Louis University.

In November 2007, Sanofi Pasteur, the vaccines division of sanofi-aventis Group, announced that it has signed a global collaboration agreement with Acambis for the development and marketing of ChimeriVax-West Nile. Under the terms of the agreement, Acambis will continue to perform development activities, up to and including the filing of a license application in the U.S. Acambis will receive an upfront payment of $10 million and would be eligible for pre- and post-marketing milestone payments of up to $70 million.

In July 2008, Sanofi-aventis announced it reached an agreement with Acambis on the terms of a unanimously recommended cash offer for the entire issued and to be issued share capital of Acambis. The acquisition was closed in September 2008.

ChimeriVax-West Nile News

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