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Eisai Co., Ltd.

Drug Names(s): E7974

Description: E7974 is a synthetic hemiasterlin analogue exhibiting binding to a and ß tubulin. It induces disruption of spindle formation and mitotic arrest characteristic of anti-tubulin cancer drugs. Unlike taxanes and vincas, E7974 is a poor substrate for the PgP drug efflux pump, potentially overcoming this common mechanism of drug resistance.

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