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Vibrilase

BioMarin Pharmaceutical Inc.

Drug Names(s): Vibriolysin Topical

Description: Vibrilase is being developed for burn debridement and has recently completed Phase I clinical trials.Vibrilase is a protease secreted by Vibrio proteolyticus, a marine microorganism. Vibrilase has the property of digesting necrotic tissue—fibrin, elastin, collagen etc. The protease activity of Vibrilase is specific for denatured proteins, leaving healthy tissue unharmed. In addition, studies in a porcine model demonstrated that Vibrilase treatment is not accompanied by bleeding, is compatible with burn treatment therapies, such as skin grafting, is stable in a hydrophilic medium at ambient temperatures and has a long shelf life.

Partners: Merck KGaA


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