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NUC B1000

Nucleonics, Inc.

Drug Names(s): Hepatitis B eiRNA Therapy, HepX

Description: The Nucleonics’ HBV clinical candidate encodes four short hairpin RNA (shRNA) molecules, each under the control of an RNA polymerase III promoter. Each of the four shRNAs targets a different segment of the HBV genome and collectively they mediate the destruction of all the different RNA molecules produced by HBV within an infected cell through RNAi. Characterization of this vector has shown that each shRNA contributes significantly to the potent antiviral effect of the vector in infected cells. Moreover, the ability to provide four different shRNAs from a single expression vector greatly reduces the potential for viral resistance to develop.

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