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Raptiva

Roche Holding AG

Drug Names(s): efalizumab, Xanelim

Description: Raptiva is a humanized monoclonal antibody that binds to an integrin (adhesion protein) present on many types of immune system cells.

Deal Structure: Revenue splits for this drug are BioMedTracker estimates.

In April 1996, Xoma and Genentech partnered to develop Raptiva. On 1/12/2005, XOMA announced the restructuring of its agreement with Genentech. Key financial elements of the new agreement included:

* The cost and profit sharing arrangement in the United States was modified. XOMA will earn a mid-single digit royalty on worldwide sales of RAPTIVA with an additional royalty rate on sales in the United States in excess of a specified level. The original agreement provided XOMA with the option of electing a royalty-only participation in RAPTIVA results, with a higher worldwide royalty rate structure, but required immediate repayment of a development loan.
* In return, Genentech agreed to discharge XOMA's obligation to pay the $40 million balance on the development loan plus accrued interest and to allow repayment of XOMA's fourth quarter share of RAPTIVA operating losses by offsetting them against future royalties...See full deal structure in Biomedtracker

Partners: XOMA Corporation Merck KGaA PDL BioPharma, Inc.


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