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Darapladib

GlaxoSmithKline plc

Drug Names(s): GSK480848, SB-480848

Description: Darapladib is an inhibitor of Lipoprotein-associated phospholipase A2 (Lp-PLA2). Lp-PLA2 is an enzyme associated with the formation of atherosclerotic plaques.

Deal Structure: Darapladib was discovered by GlaxoSmithKline, using Human Genome Sciences technology. Under the terms of an agreement signed in 1993, HGSI is entitled to receive clinical development milestone payments and royalties for compounds discovered by GlaxoSmithKline through the use of HGSI's technology and intellectual property. HGSI is entitled to receive a milestone payment if darapladib (or its backup compounds Rilapladib [GSK659032] or Goxalapadib [GSK677116]) moves through clinical development into registration and HGSI will receive royalties of up to 10% of worldwide net sales if a compound is commercialized. In addition, HGSI has an option to co-promote up to 20% in North America and Europe.

In July 2012, GlaxoSmithKline and Human Genome Sciences entered into a definitive agreement under which GSK will acquire HGS for US$14.25 per share in cash. The acquisition was completed in August 2012.


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