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AbbVie Inc.

Drug Names(s): Zotepine, Nipolept, Losizopilon, Lodopin, Majorpin, Setous, Zopite

Description: Zoleptil is an atypical antipsychotic drug with a higher affinity for the serotonin 5-HT2 receptor relative to its affinity for the dopamine D-2 receptor. Though the exact mechanism is unclear (either due to a difference in affinities for such receptors or fast dissociation from the D-2 receptor), atypical antipsychotics are able to produce an antipsychotic effect (through blockade of D-2 receptors in the ventral striatum) with fewer extrapyramidal motor function side effects (or EPSs, which are caused by blockade of D-2 receptors in the dorsal striatum).

Zotepine affects the dopamine D1 and D2, serotonin 5HT2a, 5HT2c, 5HT6, and 5HT7 receptors. In addition, it inhibits the reuptake of noradrenaline.

Partners: BASF AG Orion Corporation

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