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GlaxoSmithKline plc

Drug Names(s): PPI-2458

Description: PPI-2458 is a novel, proprietary molecule that acts by irreversibly inhibiting the enzyme methionine aminopeptidase type 2, or MetAP2. PPI-2458 is based on the fumagillin class of compounds. This class of compounds has been shown to prevent both abnormal cell growth and the formation of new blood vessels, which contribute to the growth of aberrant tissues in diseases such as cancer and rheumatoid arthritis.

Deal Structure: PPI-2458 was developed by Praecis Pharmaceuticals until the company was aquired by GlaxoSmithKline in February 2007.

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