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AstraZeneca PLC

Drug Names(s): AR806

Description: RDEA806 is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with once-daily dosing (8-13 hour half-life). In vitro preclinical tests have shown RDEA806 to be a potent inhibitor of a wide range of HIV viral isolates, including isolates that are resistant to efavirenz and other currently available NNRTIs.

Per the company, a major metabolite of RDEA806, RDEA594, is responsible for its uric acid lowering effects. RDEA594 inhibits the urate transporter in the kidney, URAT1.

Deal Structure: In December 2006, Ardea Biosciences signed a definitive asset purchase agreement with Valeant Pharmaceuticals International. Under this agreement, Ardea acquired substantially all of the assets, including intellectual property, preclinical data, product inventory, and research equipment, necessary for Ardea to pursue three distinct pharmaceutical research and development programs. The three programs are: