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Eli Lilly & Company

Drug Names(s): Oral Factor Xa Inhibitor

Description: Amgen acquired Oral Factor Xa Inhibitor on August 13, 2004 through Amgen's acquisition of Tularik.

Eli Lilly is developing an oral anticoagulant that is being studied for its utility in “prevention and treatment of thrombotic diseases.”The anticoagulant marketplace is undergoing a renaissance, with products like Sanofi-Synthelabo and Organon’s Arixtra and AstraZeneca’s Exanta showing much promise. Arixtra is a marketed parenteral formulation that, like Lilly’s compound, targets factor Xa. Exanta is oral thrombin inhibitor approaching regulatory review. Factor Xa and thrombin are intimately related, and are compelling targets for anticoagulation. Behind Arixtra and Exanta, multiple compounds approach these targets by differing means, each hoping that their pharmacology leads to superior, or at least equivalent, clinical results. Although the market is competitive, Lilly’s compound may prove to be complementary to marketed drugs. Even for a single patient, parenteral anticoagulation frequently gives way to oral anticoagulation as patients move from inpatient to outpatient settings. The reverse is also true.

Deal Structure: Eli Lilly designed this small molecule inhibitor of Factor Xa using Tulariks computer-aided molecular design (CAMD) in-silico drug discovery technology. Tularik will receive milestones and royalties.

Partners: Amgen, Inc.

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