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Artielle ImmunoTherapeutics, Inc.

Drug Names(s): RTL 1000

Description: RTL1000 is a novel protein drug with a highly-selective mechanism of action that targets pathogenic T-cells responsible for triggering and sustaining multiple sclerosis. RTL1000 disrupts the activation of the T cells, preventing the release of the inflammatory cytokines and causing the release of anti-inflammatory cytokines.

RTL1000 consists of the alpha1and beta1 domains of DR2 linked to the encephalitogenic MOG-35-55 peptide (VG312). Thus, RTL100 is designed to induce T cell tolerance to the MOG peptide thought to be associated with activated T cells in patients with multiple sclerosis.

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