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JZP-4

Jazz Pharmaceuticals plc

Drug Names(s): Type IIa sodium channel antagonist, elpetrigine

Description: JZP-4 is a Type IIa sodium channel antagonist. It is a controlled release formulation of an anticonvulsant that is in the same chemical class as Lamictal (lamotrigine), an antiepileptic/bipolar drug marketed by GlaxoSmithKline.

Deal Structure: Jazz acquired the worldwide rights to the active pharmaceutical ingredient (API) in JZP-4 from GSK in 2004. Pursuant to their agreement with GlaxoSmithKline, Jazz has paid upfront and development milestone payments of $5.0 million, and will pay $5.0 million upon first dosing of a patient in a Phase II clinical trial. The agreement with GlaxoSmithKline provides for $108.5 million in additional development and commercial milestone payments, and royalties on commercial sales.

Partners: GlaxoSmithKline plc


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