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Relistor SC

Valeant Pharmaceuticals International, Inc.

Drug Names(s): methylnaltrexone SC, MNTX subcutaneous; MOA-728; ONO-3849

Description: BioMedTracker has separate drug profiles for Relistor. Please also see Relistor (Oral) and Relistor IV.

Relistor is a mu-opioid receptor antagonist with limited ability to cross the blood-brain barrier. It is a drug designed to reverse the constipation caused by opium-based analgesics without interfering with the pain relief of opioids.

Deal Structure: Progenics and UR Labs
Progenics licensed worldwide exclusive rights to Relistor from UR Labs in October 2001.

Wyeth (now Pfizer) and Progenics
On December 23, 2005, Wyeth Pharmaceuticals and Progenics Pharmaceuticals announced that they entered into an exclusive, worldwide agreement for the joint development and commercialization of Relistor for the treatment of opioid-induced side effects, including constipation and post-operative bowel dysfunction.

Under the terms of the collaboration, Wyeth receives worldwide rights to Relistor, and Progenics retains an option to co-promote the product in the United States. The companies will collaborate on its worldwide development. The transaction includes an upfront payment of $60 million to Progenics with as much as an additional $356.5 million payable upon achievement of certain milestones. Wyeth will pay Progenics royalties on worldwide sales of Relistor and co-promotion fees within the United States. Additionally,...See full deal structure in Biomedtracker

Partners: Progenics Pharmaceuticals, Inc. Lupin Limited Swedish Orphan Biovitrum


Relistor SC News


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