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PRO 542

Progenics Pharmaceuticals, Inc.

Drug Names(s): PRO 542

Description: PRO 542 belongs to a new class of drugs, viral entry inhibitors, which are intended to prevent HIV from entering and infecting cells. PRO 542 is an antibody-like molecule which is designed to neutralize HIV by directly binding to gp120, a protein on the surface of the virus, thereby preventing HIV attachment to healthy cells within the immune system. In previous Phase I/II studies in HIV-infected patients, intravenously administered PRO 542 mediated dose-dependent and statistically significant reductions in plasma HIV RNA, a measure of HIV “viral load.” PRO 542 is currently in Phase II clinical testing in HIV-infected adults and children.

PRO 542 is a fusion protein that incorporates the HIV-binding region of the human cell surface receptor CD4 into a human antibody-like molecule. PRO 542 is designed to neutralize HIV by binding to the HIV surface glycoprotein (gp120) and preventing the virus from attaching to host cells.

Deal Structure: In October 2010, Sanofi-aventis announced it has commenced a tender offer for all outstanding shares of common stock of Genzyme for $69 per share, net to the seller in cash, without interest and less any required withholding taxes. In April 2011, Sanofi-aventis announced that it successfully completed its exchange offer for all outstanding shares of common stock of Genzyme Corporation.

Partners: Sanofi Formatech, Inc.


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