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Celldex Therapeutics, Inc.
Drug Names(s): CETi-1
Description: AVANT's cholesterol management agent, CETi-1, is designed to raise serum HDL (high-density lipoprotein) cholesterol levels by blocking the transfer of cholesterol from HDL to LDL (low-density lipoprotein). CETi-1 induces antibodies against a portion of CETP, the serum protein responsible for this transfer. HDL (often referred to as 'good' cholesterol) acts to protect against atherosclerosis while LDL (often referred to as 'bad' cholesterol) acts to promote atherosclerosis.
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