This web site is part of the Business Intelligence Division of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

RG2417

Repligen Corp.

Drug Names(s): Uridine

Description: RG2417 is a proprietary formulation of uridine, which is a biological compound essential for the synthesis of DNA and RNA. In addition, uridine is an important precursor for numerous other factors that are essential for cell metabolism. Uridine is synthesized by the mitochondria, the power plant of the human cell.

The rationale for uridine's use in bipolar depression is that in the brain, it may increase forms of cytidine and CDP-choline and thereby enhance synthesis of cell membrane phospholipids. This could impact depression, since depression has been linked to abnormalities in cell membranes, and there is some evidence suggesting that alterations of brain phospholipids composition and membrane fluidity can affect processes such as neurotransmitter-receptor binding and signal transduction. There is also evidence that a form of cytidine increases brain norepinephrine and dopamine.


RG2417 News


Additional information available to subscribers only:

  • Targets
  • Routes
  • Catalysts
  • Designations
  • Events

Request a Free Demo Subscriber Login Search for another drug