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Repligen Corp.

Drug Names(s): Uridine

Description: RG2417 is a proprietary formulation of uridine, which is a biological compound essential for the synthesis of DNA and RNA. In addition, uridine is an important precursor for numerous other factors that are essential for cell metabolism. Uridine is synthesized by the mitochondria, the power plant of the human cell.

The rationale for uridine's use in bipolar depression is that in the brain, it may increase forms of cytidine and CDP-choline and thereby enhance synthesis of cell membrane phospholipids. This could impact depression, since depression has been linked to abnormalities in cell membranes, and there is some evidence suggesting that alterations of brain phospholipids composition and membrane fluidity can affect processes such as neurotransmitter-receptor binding and signal transduction. There is also evidence that a form of cytidine increases brain norepinephrine and dopamine.

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