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AEterna Zentaris, Inc.

Drug Names(s): AN-152, ZEN-008, Zoptarelin Doxorubicin, AEZS-108

Description: AEZS-108 is a cytotoxic peptide hormone conjugatebased on luteinizing hormone-releasing hormone (LHRH) in which doxorubicin (DOX) or 2-pyrrolino-DOX respectively is linked to [D-Lys6]LHRH show high-affinity binding to the LHRH receptor,providing a selective target through receptor-mediated internalization.

Deal Structure: Aeterna and Ventana
In January 2012, Aeterna Zentaris announced it entered into a collaboration agreement with Ventana Medical Systems, a member of the Roche Group, to develop a companion diagnostic for the immunohistochemical determination of luteinizing hormone-releasing hormone (LHRH) receptor expression.

Aeterna and Ergomed
In April 2013, Aeterna Zentaris announced the signing of a co-development and profit sharing agreement with Ergomed Clinical Research for AEZS-108 in endometrial cancer. Ergomed was selected as the contract clinical development organization to conduct the multicenter, multinational, randomized Phase III trial with AEZS-108 in endometrial cancer.

Under the terms of the agreement, Ergomed will assume 30% (up to $10 million) of the clinical and regulatory costs for the Phase III trial with AEZS-108 in endometrial cancer, which are estimated at approximately $30 million over the course of the study. Ergomed will receive its...See full deal structure in Biomedtracker

Partners: Ergomed PLC Sinopharm Group Company Limited Orient Europharma Co., Ltd. Rafa Laboratories, Ltd. Specialised Therapeutics Asia Pte Ltd

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