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Eli Lilly & Company

Drug Names(s): GLP-Fc Analog, LY2189265, Torurishiti (JP)

Description: Trulicity is a fusion protein consisting of a long-acting analogue of glucagon-like peptide 1 (GLP-1) linked to the constant heavy chain (Fc) portion of an immunoglobulin (IgG4). The drug has once-weekly dosing.

It is administered using an autoinjecter with a small gauge (29 G) needle and injection volume of 0.5 mL.

GLP-1 is an incretin hormone secreted in the small intestine and colon in response to food intake. It enhances insulin secretion when glucose levels are high, suppresses inappropriate glucagons secretion (glucagon has the opposite effect of insulin), slows gastric emptying (slowing entry of ingested nutrients into the bloodstream, hence limiting post-prandial glucose), and via actions on the brain is thought to promote satiety.

Deal Structure: Revenue splits are BioMedTracker estimates.

Eli Lilly and Sumitomo Dainippon
In July 2015, Eli Lilly Japan and Sumitomo Dainippon Pharma announced that the two companies signed a sales collaboration agreement for a once-weekly GLP-1 receptor agonist Trulicity Subcutaneous Injection 0.75 mg Ateos. Based on this agreement, Eli Lilly Japan retains a manufacturing/marketing license for Trulicity and Sumitomo Dainippon Pharma takes responsibility for sales/distribution of the drug. Eli Lilly Japan and Sumitomo Dainippon Pharma will conduct activities to provide healthcare professionals with information regarding Trulicity.

Partners: Sumitomo Dainippon Pharma Co., Ltd.

Trulicity News

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